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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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血アディポネクチン,体量指数,慢性心不全患者の死亡率
Caroline Kistorp1, Jens Faber, Søren Galatius
1Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Copenhagen, Denmark. cnkistorp@dadlnet.dk
Circulation
|September 15, 2005
まとめ
高レベルのアディポネクチンは,慢性心不全 (CHF) 患者の死亡率を予測し,疾患の重症度とは無関係です. ボディマス指数 (BMI) も死亡率を予測し,アディポネクチンとNT-proBNPレベルによって媒介される可能性があります.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- メタボリックシンドロームとは
背景:
- 体重指数 (BMI) の上昇は,慢性心不全 (CHF) の予後が良くなるとの関連がある.
- アディポネクチン (Adiponectin) は,BMIと逆に関連したアディポキトキンであり,健康な個人の死亡率の予測因子である.
- アディポネクチンとCHF患者の死亡率の関係については,さらなる調査が必要である.
研究 の 目的:
- 慢性心不全 (CHF) 患者におけるプラズマアディポネクチン濃度と死亡率の関連性を調査する.
主な方法:
- 195人のCHF患者を対象とした前向きな研究.
- ベースライン測定には,プラズマアディポネクチン,N-ターミナルプロ脳ナトリウレチンペプチド (NT-proBNP),BMIが含まれていました.
- 死亡率のデータは,平均2.6年の追跡期間で収集されました.
主要な成果:
- アディポネクチンとNT-proBNPは,互いに陽性に関連しており,BMIと陰性に関連していました.
- 高レベルのアディポネクチン (上部三角体) は,CHFの重症度マーカーとNT-proBNP (HR=3.23,P=0.032) を調整した後でも,死亡率を予測しました.
- BMIは,CHFの重症度に関係なく死亡率を予測したが,NT-proBNP (HR=0.74,P=0.13) を調整した後に有意性を失った.
結論:
- アディポネクチンの濃度の上昇は,心臓発作患者の死亡率の独立した予測因子であり,おそらく衰弱を示している.
- BMIとCHFにおける死亡率との関連は,部分的にアディポネクチンとNT-proBNPによって媒介される可能性があります.
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