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関連する概念動画

COP Coated Vesicles00:59

COP Coated Vesicles

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Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
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Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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Rab Proteins01:14

Rab Proteins

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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
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Overview of Secretory Vesicles01:33

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
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液分解的に自己クロスリンク可能な共ポリマーに基づくpH反応性ベジクル.

Jianzhong Du1, Steven P Armes

  • 1Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, UK.

Journal of the American Chemical Society
|September 15, 2005
PubMed
まとめ
この要約は機械生成です。

研究者は,ユニークなコポリマーを使用して,新しいpH反応性水泡を開発しました. これらの自己組み立て,交互に結合した膀は,調節可能な透過性を示し,高度な材料アプリケーションの可能性を秘めています.

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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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関連する実験動画

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In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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科学分野:

  • ポリマー化学のポリマー化学について
  • マテリアルサイエンス 材料科学
  • ナノテクノロジー ナノテクノロジー

背景:

  • 刺激に反応する材料は,高度なアプリケーションにとって極めて重要です.
  • 膀は,カプセル化および配送のための汎用性のあるプラットフォームを提供します.
  • 膀の形態と安定性を制御することは,その有用性にとって鍵となる.

研究 の 目的:

  • 新しい形状に固執し,pHに反応する小胞を合成し,特徴づけること.
  • 特定の共ポリマーの自己組み立てと交叉結合の行動を調査する.
  • 準備した膀のpH感度と機能化の可能性を評価する.

主な方法:

  • ポリ (エチレン酸化物) -ブロックポリ (エチルメタクリレート-ステット-3-トリメトキシシリル) -プロピルメタクリレート (PEO-b-P (DEA-ステット-TMSPMA)) コポリマーの自己組み立て.
  • 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡. 膀膜壁の水解性交絡.
  • 1H NMR,TEM,DLS,および停止フローの光を用いた特徴付け.
  • 黄金のナノ粒子のインシット合成. 膀の壁内.

主要な成果:

  • 水溶液で形状に固有の安定した小胞の自発的形成.
  • 膀壁のpH反応性の透かし性を実証した.
  • 黄金のナノ粒子を膀膜に成功裏に組み込みました.
  • PEO鎖はコロナを形成し,P ((DEA-stat-TMSPMA) はpHに敏感な壁を形成した.

結論:

  • 新しく開発されたPEO-b-P ((DEA-stat-TMSPMA) コポリマーにより,強固でpHに反応する膀が作られます.
  • 水溶性クロスリンク戦略は,膀の形状を効果的に安定させます.
  • pH感受性の透過性と金ナノ粒子の装飾は,薬物投与およびセンサーにおける潜在的な応用を強調しています.