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Updated: Jul 14, 2026

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
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QM/MMモデリングによるヒトのサイトクロームP450イソフォームにおける化合物Iの電子構造

Christine M Bathelt1, Jolanta Zurek, Adrian J Mulholland

  • 1Centre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS United Kingdom.

Journal of the American Chemical Society
|September 15, 2005
PubMed
まとめ

人間のサイトクロームP450は,薬物の代謝に不可欠です. 彼らの化合物I中間体は,主要な薬物代謝イソフォームの電子構造が類似しており,タンパク質の形状は電子の違いではなく,反応性の変化を誘発しています.

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