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Updated: Jul 8, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

ヒトのタンパク質とタンパク質の相互作用ネットワーク:プロテオームの注釈のためのリソース.

Ulrich Stelzl1, Uwe Worm, Maciej Lalowski

  • 1Max Delbrueck Center for Molecular Medicine, 13092 Berlin-Buch, Germany.

Cell
|September 20, 2005
PubMed
まとめ

この研究では,酵母2ハイブリッドスクリーニングを使用して,ヒトのタンパク質とタンパク質の相互作用を体系的にマッピングし,3186の相互作用の大きなネットワークを明らかにしました. 高信頼性の相互作用が特定され,細胞経路とタンパク質の機能に関する新しい洞察を明らかにしました.

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Protein-protein Interfaces02:04

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These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...