CNTFとLIFは,IL-6信号伝達受容体 gp130のコンポーネントを含む共有信号伝達経路を通じてニューロン細胞に作用する
1Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591.
Cell
|June 26, 1992
まとめ
シリア神経栄養素因子 (CNTF) と白血病抑制因子 (LIF) は,gp130を含むシグナル伝達経路を共有し,インタールイキン-6 (IL-6) に似ています. これは,神経系と造血系の両方の重複する機能を説明します.
科学分野:
- 神経科学は神経科学である.
- 免疫学 免疫学とは
- セルラー・シグナリング
背景:
- シリア神経栄養素因子 (CNTF) は,神経系内で多様な効果を発揮する.
- 白血病阻害因子 (LIF) は,CNTFといくつかのニューロン作用を共有していますが,インタールヒキン-6 (IL-6) を真似して,非ニューロン細胞にも影響を及ぼします.
研究 の 目的:
- 神経細胞におけるCNTFとLIFのシグナル伝達機構を比較する.
- CNTF,LIF,IL-6の重複機能の根拠を解明する.
主な方法:
- ニューロン細胞系におけるCNTFとLIFによって誘発されたチロシンリン酸化と遺伝子活性化の比較.
- IL-6受容体のコンポーネント gp130.0.を伴う共有信号経路の分析
主要な成果:
- CNTFとLIFは,神経細胞における区別がつかないチロシンリン酸化と遺伝子活性化パターンを誘発する.
- これらのシグナル伝達イベントは,血液形成細胞におけるLIFとIL-6のシグナル伝達イベントとよく似ています.
- CNTFとLIFの共有信号伝達経路には,IL-6受容体システムの構成要素であるgp130が含まれています.
結論:
- CNTFの受容体系は,典型的な神経栄養因子受容体ではなく,血液生成性サイトカイン受容体に関連しています.
- gp130は,CNTFとLIFの重複するシグナル伝達機能を媒介し,神経細胞と血液細胞の応答を結びつける.
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