血栓不全の値における日経変動. 発血不全のイベントにおける昼夜変動の基礎となるメカニズム

A A Quyyumi¹, J A Panza, J G Diodati

¹Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md 20892.

Circulation

|July 1, 1992

まとめ

冠動脈疾患の患者は,心臓のイベントで昼夜間のパターンを経験します. この研究は,朝の冠動脈血管抵抗の増加を明らかにし,潜在的に心臓イベントを誘発します.

科学分野:

心臓病学心臓病学
シルカディアン生物学
血管生理学血管生理学

背景:

循環器動脈疾患 (CAD) では,心動脈イベントの日々の変動が観察される.
これらの昼夜パターンにおける冠動脈血管トーンの役割は不明である.
冠動脈血管抵抗の指標である性不全の値は,血管トーンを評価するために使用されました.

研究の目的:

安定したCADの患者における不血症の値の昼間変動を調査する.
冠動脈血管トーンの変化が心臓イベントの昼夜パターンに寄与するかどうかを判断する.

主な方法:

CAD患者の2つのグループは,1日の異なる時間帯でトレッドミルのエクササイズテストを受けました.
発血値は,心拍数または心拍数-圧力の産数として,ST低さ1mmで測定されました.
発血後前腕の血管抵抗は,ストレインゲージ・プレチスモグラフィを用いて測定した.

主要な成果:

血栓不全の値における重要な昼間変動が観察され,朝と夕方より低いことが示されました.
発血後前腕の血流は,また,午前中と夜に低くなって,昼夜間の変動を示した.
前腕の血流量と不血症の値との間に強い相関が認められた.

結論:

朝の低血栓不全の値は,イシュケミア誘発の冠動脈血管抵抗の増加を示唆しています.
前腕と冠動脈抵抗の並列の変動は,一般化された (神経的または体調的) 要因を示す.
朝の冠動脈トーンが上昇すると,一時的なイシュケミアや急性心臓発作に寄与する可能性があります.

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