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Updated: May 3, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Published on: July 29, 2014

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RNA依存タンパク質キナーゼPKRによるeIF2alphaの高次元の基板認識

Arvin C Dar1, Thomas E Dever, Frank Sicheri

  • 1Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

Cell
|September 24, 2005
PubMed
まとめ

RNA依存タンパク質キナーゼPKRは翻訳因子eIF2alphaと結合し,ウイルス感染症と戦うためにタンパク質合成を停止します. 構造分析は,PKRがSer51でeIF2alphaを認識し,リン酸化し,ウイルスの拡散を抑制する方法を明らかにしています.

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