蝙蝠はSARSのようなコロナウイルスの天然貯蔵庫です
Wendong Li1, Zhengli Shi, Meng Yu
1Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China.
まとめ
蝙蝠はSARS型コロナウイルス (SL-CoVs) の天然宿主であり,SARS型コロナウイルス (SARS-CoV) と密接に関連しています. 人間とシベットのSARS-CoV株は,コウモリに見られる多様なSL-CoV群の一部です.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 動物から伝染する病気
- エピデミオロジー エピデミオロジー
背景:
- 深刻な急性呼吸器症候群 (SARS) は2002年から2003年に発生し,その正確な起源は不明である.
- 病原体であるSARS新型コロナウイルス (SARS-CoV) は特定されていますが,その天然貯蔵庫は決定的に確立されていません.
研究 の 目的:
- SARSコロナウイルス (SARS-CoV) の天然貯蔵庫と起源を調査する.
- SARSの発生ウイルスに関連するコロナウイルスを宿す潜在的な動物宿主を特定するために.
主な方法:
- コロナウイルスの遺伝子配列の系統分析.
- バット,シベット,ヒトの孤立種間のウイルスの遺伝的多様性の比較.
主要な成果:
- SARS-CoVと密接に関連したコロナウイルスは,コウモリ種で確認されました.
- これらの蝙蝠由来ウイルスは,SARS型コロナウイルス (SL-CoVs) と呼ばれ,ヒトまたはシベットのSARS-CoVよりも大きな遺伝的多様性を示した.
- 人間とシベットのSARS-CoV単離体は,より広範なSL-CoV群に系統遺伝的に組み込まれていた.
結論:
- 蝙蝠は,SARSの発生ウイルスと密接に関連したコロナウイルスの天然貯蔵庫として機能します.
- SARSの流行ウイルスは,おそらくこのバットに関連したコロナウイルスの多様なグループから発生した.
- バットコロナウイルスを理解することは,将来の動物性感染症の発生を防ぐために非常に重要です.
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