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Updated: Jul 5, 2026

A Practical Guide to Phylogenetics for Nonexperts
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系統遺伝学MCMCアルゴリズムは,木の混合について誤解を招いている

Elchanan Mossel1, Eric Vigoda

  • 1Department of Statistics, University of California at Berkeley, Berkeley, CA 94720, USA. mossel@stat.berkeley.edu.

Science (New York, N.Y.)
|October 1, 2005
PubMed
まとめ

マルコフ連鎖モンテカルロ (MCMC) を用いたベイジアン系遺伝的推論は誤解を招く可能性があります. 私たちの研究は,MCMCアルゴリズムが収束するのに指数関数的に長い時間がかかることを示しています.

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Mismatch Repair01:36

Mismatch Repair

Overview
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Mutation, Gene Flow, and Genetic Drift

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Genetic Drift

Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.Life is not fair. A deer grazing contentedly in a field can have her meal cut tragically short by a bolt of lightning. If the doomed doe is one of only three in the population, 1/3 of the population’s gene pool is lost. Random events like this can...
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Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
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Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Survival Tree

Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
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