睡眠中に皮質の効果的な接続性の崩壊

Marcello Massimini¹, Fabio Ferrarelli, Reto Huber

¹Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.

Science (New York, N.Y.)

|October 1, 2005

まとめ

睡眠中の脳活動は,情報の伝達が低下していることを示しています. この皮質の有効な接続性の崩壊は,非急速な眼球運動睡眠中に意識が消える理由を説明するかもしれない.

科学分野:

神経科学は神経科学である.
スリープ・サイエンススリープ・サイエンス
認知神経科学とは

背景:

意識は睡眠中に消え去りますが,脳は活発です.
睡眠中の意識喪失の背後にあるメカニズムは,完全に理解されていません.
睡眠中の脳の活動パターンを調査することは,意識を理解するために非常に重要です.

研究の目的:

睡眠中の意識の消失における皮質情報伝達の役割を調査する.
1つの皮質領域の活性化が,覚醒と睡眠の間,他の脳領域にどのように広がるのかを研究する.

主な方法:

前運動皮質を活性化するために,トランスクラニアル磁気刺激 (TMS) を利用しました.
脳活動を記録するために高密度電脳図 (hd-EEG) を採用した.
接続された脳領域間のTMS誘発の皮質活性化の拡散を測定した.

主要な成果:

静かな覚醒の間,TMS誘発の活性化は,接続された皮質領域に広がった.
非急速な眼球運動睡眠の間,TMSによって引き起こされた最初の反応はより強く,しかし迅速に消えた.
皮質の活性化は,非急速な眼球運動の睡眠中に刺激部位を超えて広がるのに失敗しました.

結論:

特定の睡眠段階における意識の衰えは,皮質の効果的な接続性の崩壊と関連している可能性があります.
睡眠中の脳皮質の情報伝達が低下すると,神経信号の伝播に影響する.
これらの発見は,意識の神経基盤と睡眠中の意識の変化についての洞察を提供します.

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