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関連する概念動画

The Citric Acid Cycle02:36

The Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Disubstituted Cyclohexanes: cis-trans Isomerism02:37

Disubstituted Cyclohexanes: cis-trans Isomerism

Depending upon the different spatial orientation of the substituents, the disubstituted cycloalkanes exhibit two types of stereoisomers. The cis isomers have the substituents on the same side of the ring, whereas the trans isomers have the substituents on the opposite sides. These stereoisomers exhibit different physical properties and cannot be interconverted without breaking the carbon-carbon bonds.
In cyclohexane, the substituents can occupy different positions generating distinct isomers.
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each path...

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Updated: Jul 20, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

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オール-cisサイクルペプチド

Romuald Poteau1, Georges Trinquier

  • 1Laboratoire de Physique Quantique (CNRS, UMR5626), IRSAMC, Université Paul-Sabatier, 31062 Toulouse Cedex, France. romuald.poteau@irsamc.ups-tlse.fr

Journal of the American Chemical Society
|October 6, 2005
PubMed
まとめ

研究者は,オール-シスサイクルペプチドを調査し,それらは安定した構造であることを発見しました. これらのサイクルペプチドは,シス-アミド結合で,トランスペプチド構造に匹敵する有利な結合エネルギーを示します.

科学分野:

  • コンピューティング・ケミストリー
  • ペプチド化学 ペプチド化学
  • 構造生物学 構造生物学とは

背景:

  • アミド結合 (-NH-CO-) は,熱力学的安定性により,典型的にはトランス構成を好みます.
  • アミド結合のシス形状はエネルギー的に不利であり,線形ペプチド鎖にはステリック的な課題をもたらす.
  • サイクルペプチドは,シス-アミド結合が安定化できるユニークな構造的枠組みを提供します.

研究 の 目的:

  • 完全にシス-アミド結合から成る周期性ペプチドの構造的およびエネルギー的性質を調査する.
  • 量子計算を使用して,オール-シスサイクルペプチド構造の実現可能性と安定性を決定する.
  • 循環系におけるオール-シス対オール-トランスペプチド結合のエネルギー優位性を比較する.

主な方法:

  • B3LYPレベルの密度関数理論 (DFT) の計算が採用されました.
  • オール-シスサイクロポリグリシン (cG) (n) (c)),サイクロポリアラニン,サイクロポリフェニララニンの潜在エネルギー表面の系統的な探査.
  • アイソデミック反応と平均プラーク結合エネルギー (MPJE) を用いてリングの張力,形状の柔軟性,プラーク結合エネルギーの分析.

主要な成果:

  • オール-シスサイクルペプチド (cG (n) (c),n=2-10,15) は,潜在エネルギー表面上の真の最小値として確認されました.

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Last Updated: Jul 20, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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  • 8個のペプチド単位周辺の最適なリングサイズは,平らな構造 (cG7 ((c) からcG9 ((c)) を生み出します.
  • 小さいリングはカップのような歪みを呈し,大きいリングはの縁の形状を採用します.
  • Mean Plaque-Junction Energy (MPJE) は,オール-シスプラーク結合が6個以上の単位を持つサイクルペプチドのオール-トランス結合とエネルギー的に比較可能であることを示しています.

    • 結論:

    • オール-シスサイクルペプチドは,構造的に活力があり,熱力学的に安定しています.
    • サイクル構造におけるシス-アミド結合結合のエネルギー的な好みは,以前の仮定に異議を唱える.
    • これらのオール-シスサイクルペプチドは,潜在的自己組み立て特性を持つペプチド材料の新しいクラスを表しています.