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STIM1はCa2+センサで,CRACチャネルを活性化し,Ca2+貯蔵所からプラズマ膜に移動します

Shenyuan L Zhang1, Ying Yu, Jack Roos

  • 1Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, California 92697, USA.

Nature
|October 7, 2005
PubMed
まとめ

蓄積されたカルシウム (SOC) の流入は,細胞シグナル伝達に不可欠です. STIM1は,カルシウムセンサとして作用し,貯蔵庫が枯渇すると,血膜に移動して,カルシウム放出活性カルシウム (CRAC) チャンネルを活性化します.

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