死と関連:アポトーシスのミトコンドリア経路 (未排泄)
Diana Spierings1, Gavin McStay, Maya Saleh
1La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Science (New York, N.Y.)
|October 8, 2005
まとめ
アポプトーシスのミトコンドリア経路は,ミトコンドリア外膜浸透 (MOMP) に依存しています. Bcl-2ファミリーのタンパク質は,この重要なステップを制御し,細胞死を調節します.
科学分野:
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
- バイオケミストリー バイオケミストリー
背景:
- アポプトーシス,またはプログラム細胞死は,発達と組織ホメオスタシスに不可欠です.
- ミトコンドリア経路は,脊椎動物のアポトーシスを開始するための主要な経路です.
- ミトコンドリア外膜浸透 (MOMP) は,カスペスを活性化するタンパク質を放出する重要なイベントです.
研究 の 目的:
- アポトーシスのミトコンドリア経路を制御する分子経路を説明するために.
- MOMPの制御におけるBcl-2ファミリータンパク質の規制的役割を強調する.
- MOMPの上流と下流のシグナリングネットワークをマッピングする.
主な方法:
- 科学の信号伝達知識環境 (STKE) の接続マップデータベースを利用しました.
- アポトーシスに関与する信号伝達経路を分析し,視覚化しました.
- ミトコンドリア外膜の浸透性の調節に焦点を当てています.
主要な成果:
- アポトーシスのミトコンドリア経路は,主にMOMPの"上階"のイベントによって制御されます.
- Bcl-2ファミリータンパク質は,MOMPを媒介し制御する重要な調節体です.
- カスパースの活性化,つまり"下階"のイベントは,細胞の分解をオーケストラ化します.
結論:
- アポトーシスの調節は,MOMP制御のレベルに大きく集中しています.
- アップストリームレギュレータ,特にBcl-2タンパク質の理解は,アポプトシグナル伝達の理解に不可欠です.
- 接続マップは,これらの複雑な細胞プロセスを視覚化するための貴重なリソースを提供します.
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