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Updated: Jul 21, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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アンジオテンシン変換酵素阻害剤:新しい作用機構

Hongmei Peng1, Oscar A Carretero, Nikola Vuljaj

  • 1Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202-2689, USA.

Circulation
|October 12, 2005
PubMed
まとめ

アンジオテンシン変換酵素 (ACE) 阻害剤は,N-アセチル-セリル-アスパルチル-リシル-プロリン (Ac-SDKP) の分解を阻害することによって,高血圧における心筋線維症を減少させます. この新しいメカニズムは,炎症,細胞増殖,およびコラーゲン堆積を減少させ,新しい治療の洞察を提供します.

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