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Updated: Jul 18, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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ストロメリシン-1の強力で選択的なピロンベースの阻害剤である

David T Puerta1, John Mongan, Ba L Tran

  • 1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, and Center for Theoretical Biological Physics, University of California-San Diego, La Jolla, CA 92093, USA.

Journal of the American Chemical Society
|October 13, 2005
PubMed
まとめ

研究者らは,ヒドロキサート化合物の代替品として,新しいピロンベースのマトリックスメタルプロテインアース阻害剤 (MPI) を開発した. これらの阻害剤は,MMP-3に対する高い効能と選択性を示し,有望な新種の薬剤候補を提供する.

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