プレクタシン (Plectasin) は,サプロフィーティックな真菌から治療的可能性を秘めたペプチド抗生物質です
Per H Mygind1, Rikke L Fischer, Kirk M Schnorr
1Novozymes A/S, 2880 Bagsvaerd, Denmark.
Nature
|October 14, 2005
まとめ
菌類は,抗菌性ペプチドであるプレクタシン (plectasin) を生成し,薬剤耐性細菌に対して有効である. このデフェンシンは低毒性で治療的可能性を示し,抗生物質の新たな源を提供している.
科学分野:
- バイオケミストリー バイオケミストリー
- 微生物学 微生物学とは
- 薬理学 薬理学とは
背景:
- 動物と植物は,微生物に対して活性なペプチド抗生物質であるデフェシンを生成します.
- これらのデフェシンは,抗微生物特性を持つ小さなシステインに富んだペプチドです.
研究 の 目的:
- 菌類からの新しい防御素を特定し,特徴づけること.
- 菌類の防御素であるプレクタシンの抗菌活性と治療の可能性を評価する.
主な方法:
- 菌類Pseudoplectania nigrella.からプレクタシンを分離し,構造分析した.
- リコンビナント・プレクタシンの生産.
- 耐性菌株を含む,Streptococcus pneumoniaeに対するインビトロ抗菌検査.
- ネズミでのin vivo有効性および毒性に関する研究.
主要な成果:
- プレクタシン (plectasin) は,菌類の最初の防御蛋白であり,他の種の防御蛋白と構造的に類似している.
- 再結合プレクタシンは,高収量と純度で生産されました.
- プレクタシンは,抗生物質耐性菌株を含む,Streptococcus pneumoniaeに対する強力な活性を示した.
- プレクタシンはマウスで低毒性を示し,S. pneumoniae誘発の腹膜炎と肺炎を効果的に治療しました.
結論:
- 菌類は,抗微生物防御素の新たな源である.
- プレクタシンは,新しい抗生物質として重要な治療的可能性を秘めています.
- この発見は,様々な種においてデフェシンが共通の進化的起源を持っていることを示唆している.
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