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Updated: Jul 13, 2026

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
12:28

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

Published on: October 15, 2016

ベータペプチドの構造と機能を調整するための迅速なライブラリ画面です

Joshua A Kritzer1, Nathan W Luedtke, Elizabeth A Harker

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Journal of the American Chemical Society
|October 20, 2005
PubMed
まとめ

研究者らは,ベータ53-1.の改良されたアナログを特定するために,新しいベータペプチド合成とスクリーニング方法を開発しました. これらの新しい分子は,オンコタンパク質ヒトダブル分2 (hDM2) の結合親和性と構造特性を強化しています.

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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