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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Endocytosis01:16

Endocytosis

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Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Immune Surveillance by NK Cells and Phagocytes01:25

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
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Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells
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Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells

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食者:ファゴサイトーシスへの大きな噛み.

Deniz Ertürk-Hasdemir1, Neal Silverman

  • 1Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA.

Cell
|October 22, 2005
PubMed
まとめ
この要約は機械生成です。

特殊な血液細胞は,先天的な免疫の重要な部分である微生物を吸収します. ドロソフィラのエータースキャベンジャー受容体は,バクテリアの認識とファゴサイトゼーションに不可欠です.

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Visualizing the Early Stages of Phagocytosis
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関連する実験動画

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Visualizing the Early Stages of Phagocytosis
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"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
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科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学
  • エントモロジー エントモロジー学

背景:

  • ファゴサイトーシスは,病原菌を排除するための基本的な免疫機構です.
  • 生まれつきの免疫は,微生物の侵入から身を守るために細胞プロセスに依存しています.
  • ファゴサイトのような特殊な血液細胞は,病原体の認識と除去に不可欠です.

研究 の 目的:

  • ドロソフィラの先天免疫におけるスキャベンジャー受容体の役割を調査する.
  • 果物ハエの細菌認識とファゴサイトーシスに関与する特定の分子を特定するために.
  • ホスト-病原体相互作用の文脈におけるエーター受容体の機能を明らかにする.

主な方法:

  • Drosophila melanogasterをモデル生物として利用しました.
  • ファゴシトーシスを研究するために,遺伝的および細胞測定法を使用しました.
  • 免疫反応におけるイーター・スキャベンジャー受容体の機能を調査した.

主要な成果:

  • Eaterが免疫認識に不可欠なスキャベンジャー受容体であることを実証しました.
  • Showned Eaterは,ドロソフィラのバクテリアのファゴシトーシスを媒介する.
  • フルーツフライの微生物病原体に対する防御におけるエーターの重要性を強調した.

結論:

  • イータースキャベンジャー受容体は,ドロソフィラの先天的な免疫系において重要な役割を果たします.
  • イーターは,特殊な血液細胞によってバクテリアの認識と吸収を促進します.
  • この発見は,種間のファゴサイトーシスの保存されたメカニズムについての洞察を提供します.