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関連する概念動画

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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関連する実験動画

Updated: Jul 13, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
09:50

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

相互に結びついた高速と遅いポジティブなフィードバックループは,信頼性の高い細胞決定を推進します.

Onn Brandman1, James E Ferrell, Rong Li

  • 1Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA. onn@stanford.edu

Science (New York, N.Y.)
|October 22, 2005
PubMed
まとめ

ポジティブフィードバックシステムは,単一のループではなく,複数のリンクされたループを使用して,騒音に抵抗しながら迅速な応答を達成します. この二重タイムスイッチメカニズムは,細胞の偏極化や信号伝達などの生物学的プロセスに不可欠です.

科学分野:

  • システム生物学 システム生物学
  • 分子生物学は分子生物学である.
  • バイオフィジックス 生物物理学

背景:

  • ポジティブなフィードバックは,生物学的信号伝達における一般的なモチーフです.
  • それは,システムが段階的な入力から決定的な,すべてまたは何もない出力に切り替えることを可能にします.
  • 例として,細胞の極化,カルシウムシグナル伝達,卵細胞の成熟などがあります.

研究 の 目的:

  • 生物学的なシステムが単一のループではなく,複数の相互接続されたポジティブなフィードバックループを使用する理由を調査する.
  • 頑丈な生物学的スイッチの背後にある設計原理を理解する.

主な方法:

  • 数学的モデリングとシミュレーションが採用されました.
  • この研究は,リンクされた高速および遅いポジティブなフィードバックループのダイナミクスに焦点を当てました.

主要な成果:

  • 速いフィードバックループと遅いフィードバックループを結びつけることで",二重時間"のスイッチが作られます.
  • この二重時間スイッチは,迅速に誘導されます.
  • また,上流信号からの騒音に対する有意な耐性を示しています.

さらに関連する動画

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

関連する実験動画

Last Updated: Jul 13, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
09:50

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

結論:

  • 複数の相互接続されたポジティブフィードバックループは,単一ループよりも利点があります.
  • "ダブルタイム"スイッチは,強固で迅速な生物学的反応のためのメカニズムを提供します.
  • この設計原理は,様々な生物学的プロセスにわたって保たれています.