関連する実験動画

Updated: May 15, 2026

Assaying Protein Kinase Activity with Radiolabeled ATP
08:05

Assaying Protein Kinase Activity with Radiolabeled ATP

Published on: May 26, 2017

AID抗体多様化酵素は,タンパク質キナーゼAのリン酸化によって調節される

Uttiya Basu1, Jayanta Chaudhuri, Craig Alpert

  • 1The Howard Hughes Medical Institute, The Children's Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|October 28, 2005
PubMed
まとめ

タンパク質キナーゼA (PKA) は活性化誘発型シチジンデアミナーゼ (AID) をリン酸化し,B細胞における抗体多様化のためのDNAターゲティング能力を高めます. この翻訳後の改変は,抗体クラススイッチ再結合 (CSR) と体性ハイパーミューテーションにおいて極めて重要です.

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Phosphorylation01:02

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Protein Kinases and Phosphatases02:54

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