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Updated: May 10, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

遺伝子発現におけるアクティベーターのターンオーバーに対する推定的な刺激作用

J Russell Lipford1, Geoffrey T Smith, Yong Chi

  • 1Howard Hughes Medical Institute, Division of Biology, MC 156-29, California Institute of Technology, 1200 E. California Boulevard, Pasadena, California 91125, USA.

Nature
|November 4, 2005
PubMed
まとめ

ユビキチン-プロテアソームシステム (UPS) は,転写活性化剤を分解しますが,このタンパク質解離は逆説的に遺伝子発現を高めることができます. プロテアソームを阻害すると,Gcn4.4のような重要な酵母活性化剤の機能が損なわれます.

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AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

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