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Conservation of Declining Populations02:07

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Termination of Translation

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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A High Performance Impedance-based Platform for Evaporation Rate Detection
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A High Performance Impedance-based Platform for Evaporation Rate Detection

Published on: October 17, 2016

[12]キャンセルする.

Matthew N Gard1, Matthew K Kiesewetter, Richard C Reiter

  • 1Department of Chemistry, Illinois State University, Normal, Illinois 61790-4160, USA.

Journal of the American Chemical Society
|November 17, 2005
PubMed
まとめ
この要約は機械生成です。

研究者らは,ベンゼンの脱水アナログである [12]annulyne のいくつかの同位体を生成しました. 酸素に敏感なこれらの化合物は,安定した芳香性ダイアニオンに還元され,カチオン相互作用によりユニークな陽子NMR信号を明らかにすることができます.

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科学分野:

  • 有機化学 オーガニック・ケミストリー
  • アロマティック性研究
  • アヌレンの合成

背景:

  • ベンゼンのデヒドロアナログであるo-ベンジン ([6]annulyne) は単一の同位体として存在する.
  • より大きなデヒドロアヌレンの合成と性質は,まだあまり研究されていない.
  • アヌレネイソマーの理解は,アロマティック性と電子構造の探査に不可欠です.

研究 の 目的:

  • [12]annulyneの様々な同位体を合成し,特徴づけること.
  • これらの [12]annulyneイソマーの電子特性と安定性を調査する.
  • [12]annulynesとその縮小された形態の振る舞いを探求する.

主な方法:

  • 1,5-ヘクサジンの自己凝縮は,カリウムテルト-ブトオキシドを用いて行われます.
  • ヘクサブロモサイクロドデセンの完全な脱水ハロゲン化.
  • 1HのNMRスペクトロスコーピーは,リング電流効果と陽子共鳴を分析します.
  • 電子化学的還元によりダイアニオンを形成する.

主要な成果:

  • [12]アヌリネの2つの同位体 (3,11-di-transと5,9-di-trans) は自己凝縮によって合成され,弱いパラトロピックリング電流と酸素感性を示した.
  • 3つ目の,より不安定な同位体 (3,9-di-trans-[12]annulyne) は,脱水ハロゲン化によって得られた.
  • 両方の合成アイソマーは,それぞれの安定したダイアトロピクダイアニオンに還元できる.
  • カリウムカチオンとアルキンp (y) -オービタルの間の密接な関連は,異常に低いフィールドの陽子NMR共鳴を引き起こしました.

結論:

  • [12]アヌリネの複数のイソマーを合成することができ,デヒドロアヌリネ化学の範囲を拡大します.
  • アロマティック性 (ダイアニオンで二酸化性として表される) を含む電子特性は,同位体に依存しています.
  • カウンテリオンとアンネルン系との相互作用は,それらのスペクトル学的性質に大きな影響を与えます.