妊娠の特徴と母乳がんのリスク

Sven Cnattingius¹, Anna Torrång, Anders Ekbom

¹Department of Medical Epidemiology and Biostatistics, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden. sven.cnattingius@mep.ki.se

JAMA

|November 17, 2005

まとめ

妊娠中の胎盤の体重の増加は,母乳がんのリスクの増加と関連しています. この発見は,妊娠ホルモンが乳がんの発症における役割を裏付けるものである.

科学分野:

生殖内分泌学生殖内分泌学
腫瘍学腫瘍学
エピデミオロジーエピデミオロジー

背景:

妊娠には,主に胎盤からのホルモン (エストロゲン,プロゲステロン) のレベルが著しく上昇します.
胎盤の特徴は,妊娠中の母親のホルモン被曝の間接的なマーカーとして機能する可能性があります.
以前の研究では,妊娠マーカーと後の母乳がんのリスクとの関連が矛盾していることが示されています.

研究の目的:

妊娠中のホルモン暴露の間接的なマーカー,特に胎盤の体重と乳がんの発症リスクとの関係を調査する.
他の妊娠の特徴と母乳がんのリスクとの関連性を調べる.

主な方法:

スウェーデンの健康記録 (出生記録,がん記録,死因記録,人口記録) を利用した人口ベースのコホート研究.
1982年から1989年の間にシングレットを産んだ女性を含み,2001年まで追跡された.
コックス比例リスクモデルを使用して,胎盤の体重と乳がん発生率の関連性を分析しました.

主要な成果:

314,019人の女性のうち,2216人が乳がんを発症し,95%が50歳以前に診断されました.
妊娠中の胎盤の重さは500~699g,妊娠中の胎盤の重さは700g以上で,妊娠中の胎盤の重さが500~699g以上で,妊娠中の胎盤の重さは700g以上で,妊娠中の胎盤の重さは500~699g以上で,妊娠中の胎盤の重さは500~699g以上で,妊娠中の胎盤の重さは500~699g以上で,妊娠中の胎盤の重さは500~699gで,妊娠中の胎盤の重さは500~699gで,妊娠中の胎盤の重さは500~699gで,妊娠中の胎盤の重さは500~650gで,妊娠中の胎盤の重さは500~650gで,妊娠中の胎盤の重さは500~650gで,妊娠中の胎盤の重さは500~650gで,妊娠中の胎盤の重さは1.82倍に増加しました.
両方の妊娠で胎盤の体重が700g以上であった女性は,乳がんのリスクが2.05倍に増加しました.

結論:

胎盤の体重は,母親の乳がんリスクと正の関連性を示しています.
これらの発見は,妊娠ホルモンが後世で乳がんを発症するリスクに大きな影響を与えるという仮説を裏付けている.

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