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Updated: Jun 25, 2026

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
14:33

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species

Published on: August 30, 2012

DISC1とPDE4Bは,統合失調症における相互作用する遺伝因子であり,cAMPシグナル伝達を調節する

J Kirsty Millar1, Benjamin S Pickard, Shaun Mackie

  • 1Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK. Kirsty.Millar@ed.ac.uk

Science (New York, N.Y.)
|November 19, 2005
PubMed
まとめ

統合失調症1型障害 (DISC1) タンパク質は,精神疾患に関連する遺伝子であるフォスフォディエステラーゼ4B (PDE4B) と相互作用する. DISC1は,細胞シグナル伝達に対する反応としてPDE4Bの活性を調節し,統合失調症のメカニズムに関する新しい洞察を提供します.

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