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Updated: Jul 11, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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変異したTCR信号は,幾何学的にパターンを変更した免疫シナプスから発信される

Kaspar D Mossman1, Gabriele Campi, Jay T Groves

  • 1Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|November 19, 2005
PubMed
まとめ

この研究は,T細胞受容体の位置付けが免疫細胞の信号伝達をどのように調節するかを明らかにしています. T細胞受容体を特定の領域に機械的に閉じ込めることで,信号伝達が長引くようになり,空間的制御が免疫反応の鍵であることを示唆しています.

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