リンフォカインで活性化されたマクロファージによるコラーゲンアースの生成

L M Wahl, S M Wahl, S E Mergenhagen

Science (New York, N.Y.)

|January 24, 1975

まとめ

刺激されたの細胞はリンパホキンを放出し,マクロファージがコラーゲナースを生成する. これは,マクロファージコラーゲナースが慢性炎症性病変でコラーゲンを分解する可能性があることを示唆しています.

科学分野:

免疫学免疫学とは
細胞生物学細胞生物学
バイオケミストリーバイオケミストリー

背景:

コラーゲンの分解は,慢性炎症状態の特徴です.
これらの病変におけるコラーゲンの分解を駆動する特定の細胞機構は,完全に理解されていません.

研究の目的:

の細胞産物 (リンフォキーン) がマクロファージによるコラーゲナース生成を誘発する役割を調査する.
マクロファージ由来のコラーゲナーゼが炎症性環境でコラーゲンの分解に寄与するかどうかを判断する.

主な方法:

マクロファージをミトゲンおよびアンチゲン刺激リンパ球から派生したリンパホキンでインキュベーションする.
化マクロファージにおけるコラーゲナース活性に対する測定.

主要な成果:

刺激された臓細胞によって分泌されるリンパホキンを被曝したマクロファージは,コラーゲナース生成を示した.
コラーゲネーゼを誘発できる活性リンパホキンは,ミトゲンと抗原の両方の刺激リンパ球から分離されました.

結論:

刺激されたリンパ球によって分泌されるリンパホキンは,マクロファージを誘導してコラーゲナースを生成する.
マクロファージコラーゲナゼは,慢性炎症性病変で観察されるコラーゲン分解の潜在的な媒介です.

さらに関連する動画

05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 6, 2013

09:49

A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines

Published on: January 14, 2017

関連する概念動画

01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

関連する実験動画