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関連する概念動画

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)01:22

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...
Angle of Twist - Elastic Range01:13

Angle of Twist - Elastic Range

Consider a cylindrical shaft with a length denoted by L and a consistent cross-sectional radius referred to as r. This shaft undergoes a torque at the free end. The highest shearing strain within the shaft is directly proportional to the twist angle and the radial distance from the shaft axis. When the shaft behaves elastically, this shearing strain can be articulated using variables such as the applied torque, radial distance, the polar moment of inertia, and the modulus of rigidity. By...
Angle of Twist: Problem Solving01:13

Angle of Twist: Problem Solving

An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the torque exerted...

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関連する実験動画

Updated: Jul 19, 2026

Fabricating van der Waals Heterostructures with Precise Rotational Alignment
09:25

Fabricating van der Waals Heterostructures with Precise Rotational Alignment

Published on: July 5, 2019

ハイブリッドペプチド配列のポリペプチドヘリックス

Kuppanna Ananda1, Prema G Vasudev, Anindita Sengupta

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Journal of the American Chemical Society
|November 25, 2005
PubMed
まとめ

研究者らは,アルファ,ベータ,ガンマ残基を用いた新しいポリペプチドヘリクスを記述しています. (alpha alphabeta) nと (alphagamma) nを含むこれらのハイブリッド配列は,結晶形状のユニークな拡張ヘリクルス回転と繰り返し構造を示しています.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 構造生物学 構造生物学とは
  • 有機化学 オーガニック・ケミストリー

背景:

  • ポリペプチドヘリクスは,タンパク質の構造と機能に不可欠です.
  • 多種多様なアミノ酸タイプを組み込んだハイブリッド配列は,新しい構成可能性を提供します.
  • これらの構造を理解することは,新しい生体材料と治療法を設計する上で鍵となるものです.

研究 の 目的:

  • ハイブリッド配列によって形成されるポリペプチドヘリクスの新しいクラスについて説明する.
  • アルファ,ベータ,ガンマ残基を含む合成ペプチドの分子構成を決定する.
  • 拡張された螺旋回転と新しい水素結合構造の可能性を調査する.

主な方法:

  • 合成ペプチドの分子構成を決定するために,X線結晶学を用いた.
  • 結晶構造の分析により,特定の水素結合単位 (例えばC14,C12) を有する繰り返しの螺旋構造が明らかになった.
  • 実験的に決定されたバックボーン・トルション・アングルは,エネルギー的に有利なハイブリッドヘリを生成するために使用されました.

主要な成果:

  • ハイブリッド配列 (alpha alphabeta) nおよび (alphagamma) nのポリペプチドヘリクスの新しいクラスが特定されました.

さらに関連する動画

Operation of the Collaborative Composite Manufacturing (CCM) System
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Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

関連する実験動画

Last Updated: Jul 19, 2026

Fabricating van der Waals Heterostructures with Precise Rotational Alignment
09:25

Fabricating van der Waals Heterostructures with Precise Rotational Alignment

Published on: July 5, 2019

Operation of the Collaborative Composite Manufacturing (CCM) System
10:09

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

  • ペプチド1は,C14の水素結合ユニットと重複する螺旋構造を示した.
  • ペプチド2は,C12の水素結合ユニットと重複する螺旋構造を示した.
  • ハイブリッドシーケンスにおけるC11からC15ヘリ用の適合パラメータが提供されました.

    • 結論:

    • アルファ,ベータ,ガンマ残基を含むハイブリッド配列は,拡張回転を持つ新しいポリペプチドヘリクスを形成することができます.
    • この研究は,これらのハイブリッドヘリコプターの構造的多様性と構成パラメータに関する洞察を提供します.
    • これらの発見は,パーソナライズされた構造的,機能的特性を備えたペプチドの設計に役立つかもしれない.