関連する実験動画

Updated: May 2, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.7K

プロトコルダト基因相容性局の分離と特徴付け

Anthony W De Tomaso1, Spencer V Nyholm, Karla J Palmeri

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA. tdet@stanford.edu

Nature
|November 25, 2005
PubMed
まとめ

研究者は,免疫システムの進化の洞察を提供, histocompatibilityを制御する tunicatesで新しい遺伝子を特定しました. この発見は,脊椎動物免疫の起源と自己認識の普遍的な生物学的プロセスに光を当てています.

さらに関連する動画

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.8K
Chromatin Immunoprecipitation in the Cnidarian Model System Exaiptasia diaphana11:48

Chromatin Immunoprecipitation in the Cnidarian Model System Exaiptasia diaphana

Published on: March 17, 2023

2.3K

関連する概念動画

Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.1K
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
22.5K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
5.7K