アフリカにおける心筋病の流行病学と病因学
Karen Sliwa1, Albertino Damasceno, Bongani M Mayosi
1Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.
Circulation
|December 7, 2005
まとめ
心筋病はアフリカで一般的であり,心不全の主な原因は膨張型と周周型である. 多様な原因を理解し,予防と治療戦略を改善するためにさらなる研究が必要である.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 心筋病は,アフリカで蔓延し,重篤な心筋疾患である.
- これは,アフリカ大陸全土で患者さんの不良の結果と関連しています.
研究 の 目的:
- アフリカにおける心臓筋病の現在の疫学と病因をレビューする.
- 地域における心臓筋疾患の研究における研究ギャップと将来の方向性を特定する.
主な方法:
- MEDLINEと記事参照リスト (1966-2005) の包括的な文献検索.
- アフリカにおける様々なタイプの心筋病の流行病学的データと病因学的要因の合成.
主要な成果:
- 拡張性心筋症は,世界の他の地域とは異なり,アフリカにおける心不全の主な原因です.
- 産前期心筋病は広範囲に広がっており,出産の発生率は1:1000から1:100です.
- エンドミオカルディアス線維症は地理的に熱帯アフリカに限定されており,地理,食事,感染症,エオシノフィリアと関連があると考えられています.
- ハイパルトロフィックおよびリズム不振性右心室性心筋症候群は,全局的なプレゼンテーションに類似するように見えます.
結論:
- 拡張性および周回性心筋病変の病原性において,重要な地域差異が存在する.
- 大規模な疫学研究は,アフリカにおける心筋病の発生,流行,結果を理解するために不可欠です.
- このような研究は,大陸全体で効果的な予防と治療戦略を開発するために不可欠です.
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