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Updated: Jul 18, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
11:36

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing

Published on: July 3, 2016

ベータ-ラクタムと類似したベータ-スルタムとセリンベータ-ラクタマゼの反応の異なる移行状態構造

Wing Y Tsang1, Naveed Ahmed, Paul S Hinchliffe

  • 1Department of Chemical and Biological Sciences, The University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.

Journal of the American Chemical Society
|December 8, 2005
PubMed
まとめ

N-アシルβ-スルタムは,スルフォニレーションによってCクラスβ-ラクタマースを無活性化し,メカニズム的にはβ-ラクタムと異なる. これらの新種の不活性化剤は,酵素反応における異なった移行状態を明らかにし,β-ラクタマース阻害に関する洞察を提供します.

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