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Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Upper Respiratory Drugs: Decongestants01:27

Upper Respiratory Drugs: Decongestants

Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in various...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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関連する実験動画

Updated: Jul 14, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

アスコルビック酸は風邪を治す. 予防と治療のための臨床試験です.

T R Karlowski, T C Chalmers, L D Frenkel

    JAMA
    |March 10, 1975
    PubMed
    まとめ

    アスコルビン酸 (ビタミンC) は,9ヶ月の研究で,風邪の持続時間と重度に最小限の影響を及ぼしました. 観察された効果は,参加者がダブルブラインドプロトコルを破ったことによって影響を受けた可能性があります.

    科学分野:

    • 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
    • 公衆衛生は公衆衛生である.
    • クリニック・リサーチ 臨床研究

    背景:

    • 風邪は,生産性に大きな影響を与える流行病であり続けています.
    • アスコルビン酸 (ビタミンC) は,科学的な証拠が議論されているが,風邪を予防または治療すると広く信じられています.

    研究 の 目的:

    • 普通の風邪の持続時間と重症度を減らすために,高用量のアスコルビック酸サプリメントの有効性を調査する.
    • コントロール試験における風邪の発生率と中退率に対するアスコルビン酸の影響を評価する.

    主な方法:

    • ナショナル・インスティテュート・オブ・ヘルス (National Institutes of Health) の従業員311人を対象とした9ヶ月のダブルブラインド・プラセボ対照試験です.
    • 参加者は,アスコルビック酸1gmまたはラクトースプラセボを1日3回,風邪の発症時に1日3gmを摂取しました.
    • 脱落率をモニタリングし,脱落は少なくとも1ヶ月の試験薬の欠落として定義された.

    主要な成果:

    • 研究を完了したボランティアはわずか190人であったが,中退率はアスコルビック酸グループ (34%) よりもプラセボグループ (44%) で高かった.

    さらに関連する動画

    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
    16:56

    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

    Published on: August 30, 2014

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
    09:17

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

    Published on: January 2, 2017

    関連する実験動画

    Last Updated: Jul 14, 2026

    A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
    11:56

    A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

    Published on: April 11, 2014

    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
    16:56

    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

    Published on: August 30, 2014

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
    09:17

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

    Published on: January 2, 2017

  • アスコルビック酸は,風邪の持続時間と重症度に対して,少なくともわずかな影響を示した.
  • 観察された効果は,ダブルブラインド条件の違反に潜在的に起因する可能性があります.

    • 結論:

    • 高用量のアスコルビック酸サプリメントは,風邪の症状に限られた効果があるようです.
    • これらの発見を確認し,アデレンスや盲目的な整合性などの潜在的な混乱要因を探るため,さらなる研究が必要です.