クロマチンの組織と細胞の運命のスイッチは,アラビドプシスの位置情報に反応する
1Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
Nature
|December 20, 2005
まとめ
植物細胞は,その位置によって運命を変えることができる. アラビドプシスの根で,GLABRA2 (GL2) 遺伝子の周りのクロマチンの組織は,細胞分裂中にリセットされ,細胞運命を変化させ,発達の可塑性を可能にします.
科学分野:
- 植物発達生物学 植物発達生物学
- 細胞の可塑性について
- エピジェネティクス エピジェネティクス
背景:
- 植物細胞は発達的な可塑性を発揮し,環境のシグナルが変化したときに運命を切り替えることができる.
- アラビドプシスの根では,表皮細胞は,位置情報とGLABRA2 (GL2) 転写因子活性に基づいて,毛細胞と非毛細胞に分離する.
研究 の 目的:
- アラビドプシス (Arabidopsis) 根の表皮における位置依存性細胞型特異におけるクロマチン組織の役割を調査する.
- 細胞が新しいポジショナルの環境に移動すると,細胞の運命の変化がどのように起こるかを理解する.
主な方法:
- 無傷なアラビドプシスの根の表皮組織に立体的な光 in situ ハイブリダイゼーション (3D FISH).
- GLABRA2 (GL2) 場所の周りのクロマチンの組織の分析.
- 非典型の細胞分裂後の細胞運命の変化を追跡する.
主要な成果:
- GL2ロカス周辺の代替クロマチンの組織状態は,細胞型特異を制御するために極めて重要です.
- 細胞が新しいファイルに移動すると,GL2周辺のクロマチンの状態は継承されるのではなく,再編成される.
- クロマチンの改造は,局所的な位置情報に対する反応として,細胞周期のG1期間に起こります.
結論:
- GL2場所の周りのクロマチンの改造は,アラビドプシスの根の表皮における細胞運命の可塑性を裏付ける重要なメカニズムです.
- 植物細胞のクロマチンの組織を動的に変化させる能力は,発達の可塑性に対するその能力を支持する.
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