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Updated: Jul 9, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

残存二極結合を用いたネイティブアルファ-シナヌクレインの長距離秩序と局所的な乱れを定義する

Pau Bernadó1, Carlos W Bertoncini, Christian Griesinger

  • 1Institute de Biologie Structurale Jean-Pierre Ebel, CNRS-CEA-UJF, 41 rue Jules Horowitz, 38027-Grenoble Cedex, France.

Journal of the American Chemical Society
|December 22, 2005
PubMed
まとめ

この研究は,残留二極結合 (RDC) が本質的に非構造タンパク質の長距離構造秩序を検出する方法を示しています. この画期的な発見は,パーキンソン病に関連するアルファ-シヌクレインのようなタンパク質を理解するのに役立ちます.

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