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Updated: Feb 14, 2026

Author Spotlight: Understanding DNA Damage Response in Mammalian Oocytes and Preimplantation Embryos
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Author Spotlight: Understanding DNA Damage Response in Mammalian Oocytes and Preimplantation Embryos

Published on: June 23, 2023

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MDC1は,リン酸化ヒストーンH2AXを直接結合して,DNA二重鎖の断裂に対する細胞の反応を調節する

Manuel Stucki1, Julie A Clapperton, Duaa Mohammad

  • 1The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, Cambridge University, Tennis Court Road, Cambridge CB2 1QN, United Kingdom.

Cell
|December 27, 2005
PubMed
まとめ

哺乳類のMDC1/NFBD1タンパク質は,DNA損傷反応における重要な信号である,リン酸化H2AX (ガンマH2AX) に結合する. この相互作用は,DNA修復の調節と,DNA損傷後のゲノム安定の維持に不可欠です.

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