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Updated: May 5, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

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クリオピリンは,毒素とATPへの反応として炎症体を活性化します

Sanjeev Mariathasan1, David S Weiss, Kim Newton

  • 1Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|January 13, 2006
PubMed
まとめ

クリオピリンは,ATPやバクテリアの成分のような特定のトリガーによる炎症体の活性化に不可欠です. この先天的な免疫経路は,重要な炎症性サイトカインであるインタールイキン-1βおよびインタールイキン-18.0を処理するために,クリオピリンを必要とします.

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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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The Extrinsic Apoptotic Pathway

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Inflammatory Response

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