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Updated: Jul 10, 2026

Identification of Growth Inhibition Phenotypes Induced by Expression of Bacterial Type III Effectors in Yeast
09:34

Identification of Growth Inhibition Phenotypes Induced by Expression of Bacterial Type III Effectors in Yeast

Published on: March 30, 2010

Gタンパク質模倣機能を持つバクテリアのIII型エフェクターファミリーの特定

Neal M Alto1, Feng Shao, Cheri S Lazar

  • 1Department of Pharmacology, Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|January 18, 2006
PubMed
まとめ

細菌の病原体は,宿主細胞のGTPaseシグナル伝達を模倣するエフェクタータンパク質を注入し,RhoA,Rac1,Cdc42. 感染症に不可欠なこれらの機能的模倣者は,活動のために保存されたWxxxEモチーフを使用します.

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Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions

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Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing10:29

Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Published on: July 6, 2016

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G-protein Coupled Receptors

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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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Activation and Inactivation of G Proteins

Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...
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GPCRs Regulate Adenylyl Cylase Activity

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Two...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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Transducer Mechanism: G Protein–Coupled Receptors

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GPCRs are also called heptahelical, 7TM, or...