勃起不全とそれに伴う心血管疾患

Ian M Thompson¹, Catherine M Tangen, Phyllis J Goodman

¹Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. thompsoni@uthscsa.edu

JAMA

|January 18, 2006

まとめ

勃起不全 (ED) は,55歳以上の男性における心血管疾患のリスクが高いことと関連しています. EDは,基礎となる心血管疾患をシグナルし,リスク因子評価と介入を正当化します.

科学分野:

心臓病学心臓病学
泌尿器科泌尿器科とは
予防医学は,予防的な医療です.

背景:

心血管疾患 (CVD) と勃起不全 (ED) は,共通の危険因子を共有しています.
EDとCVDの関連性を調べることは,早期発見と予防に不可欠です.

研究の目的:

勃起不全と,その後の心血管疾患の発生との関連を調べる.
EDが心血管疾患の早期指標として機能するかどうかを判断する.

主な方法:

前立腺がん予防試験 (プラセボグループ) の55歳以上の9457人の男性を対象に,CVDとEDをモニタリングした.
相対的な危険性回帰モデルは,複数の共変数を調整して,関連性を分析するために使用されました.
データ収集は1994年から2003年の間に実施され,定期的な3ヶ月のフォローアップが行われました.

主要な成果:

既往のCVDのない男性の47%で,研究開始時に勃起不全が流行していた.
5年後に発生したEDは,その後の心血管疾患のリスクが25%増加した (HR=1.25,P=.04).
流行またはインシデントEDを有する男性は,心血管疾患のリスクが45%高かった (HR=1.45,P<.001),喫煙または家族歴の心筋梗塞のリスクに匹敵する.

結論:

勃起不全は,男性における心血管疾患の臨床イベントの早期警告信号である可能性があります.
EDの存在は,心血管疾患の危険因子の徹底的な調査と管理を必要とします.

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