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Updated: Jun 27, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

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エピジェネティックサイレンサーとノッチは,Rbサイレンシングによって悪性腫瘍を促進するために協力しています

Dolors Ferres-Marco1, Irene Gutierrez-Garcia, Diana M Vallejo

  • 1Instituto de Neurociencias CSIC-UMH, Campus de San Juan, Apartado 18, 03550 Sant Joan, Alicante, Spain.

Nature
|January 27, 2006
PubMed
まとめ

研究者らは,がんの発症に関与する2つのエピジェネティックサイレンサー,ピプスクイークとロラを特定しました. デルタの過剰発現と併せて,それらの解調は,ヒストンの改変とDNAメチル化に影響を与えることで,転移性腫瘍の形成を促進する.

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X-chromosome...
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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