アスキディアンスの細胞行動にコード系遺伝子ネットワークをリンクする
Brad Davidson1, Lionel Christiaen
1Department of Molecular and Cellular Biology, Division of Genetics & Development, University of California, Berkeley, 94720, USA. bandi@berkeley.edu
Cell
|January 28, 2006
まとめ
数少ない透明な細胞と急速な発達を持つアシディアン胚は,体内画像を用いて細胞系を研究するのに理想的です. 彼らの遺伝的単純さは,研究者が遺伝子ネットワークを,形質変異を駆動する細胞プロセスと接続することを可能にします.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- 細胞生物学 細胞生物学
背景:
- アシディアン (アシディアン) は,透明な胚を持つシンプルなコード動物です.
- 彼らの胚は細胞が少ないので,急速に発達します.
- アシディアの遺伝子は単純で,限られた冗長性とコンパクトな規制領域を特徴としています.
研究 の 目的:
- 生物学的研究のためにアシディアン胚のシンプルさを活用する.
- 総合的な遺伝子ネットワークを,形質変異における細胞の出来事と結びつける.
- ラベル付けされた細胞系統のインビボ光成像を可能にします.
主な方法:
- 透明性と急速な発達のためにアシディアン胚を使用しています.
- in vivo光成像技術を使用しています.
- ネットワークマッピングのための遺伝的単純性を分析する.
主要な成果:
- アシディアン胚におけるインビボ画像の実現可能性を実証した.
- 遺伝子ネットワークを発達プロセスに結びつけるモデルを確立した.
- モルフォゲネシスの研究におけるアシディアの有用性を強調した.
結論:
- アスキディアン胚は,発達を研究するための強力なモデルシステムを提供します.
- 細胞と遺伝子のシンプルさの組み合わせは,遺伝子ネットワーク分析を容易にする.
- このアプローチは,単純な状動物における形態変異の理解を前進させる.
関連する概念動画
02:54Evolutionary Relationships through Genome Comparisons
5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
02:31Synteny and Evolution
2.9K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
2.9K
02:34DNA Microarrays
16.8K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
16.8K
02:46Genetic Screens
4.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.6K
01:22Diversity in Cell Signaling Responses
7.1K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
7.1K
01:29Somatic to iPS Cell Reprogramming
2.1K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.1K