慢性衰弱症の鹿の骨格筋におけるプリオン
Rachel C Angers1, Shawn R Browning, Tanya S Seward
1Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Science (New York, N.Y.)
|January 28, 2006
まとめ
慢性疲労症 (CWD) のプリオンは,鹿の骨格筋に存在しています. 感染した鹿の肉を食べたり,扱ったりすると,ヒトがプリオンに曝される危険性があります.
科学分野:
- プリオン生物学と動物性感染症
- 野生生物の健康と食品の安全について
背景:
- 慢性疲労症 (CWD) は,鹿類において地理的に広がっています.
- 牛のスポンジ状脳症 (BSE) に似たCWDの動物性感染症の可能性に関して懸念があります.
- 肉の消費は,CWDのプリオンにヒトが潜在的に曝露する主な経路です.
研究 の 目的:
- CWDに罹患したサービッドの骨格筋におけるプリオン感染性を調査する.
- 肉の消費または取り扱いを通じて,人間にプリオン被曝のリスクを評価する.
主な方法:
- バイオアッセイは,鹿類のプリオンタンパク質を発現させるように設計されたトランスジェニックマウスを用いて実施した.
- これらのマウスは,CWDに感染した鹿のサンプルの感染性プリオンを検出するために使用されました.
主要な成果:
- CWDに感染した鹿の骨格筋に感染性プリオンが検出されました.
- この発見は,人間が一般的に消費する組織にプリオンの存在を確認しています.
結論:
- CWDに感染した鹿の骨格筋には,プリオン感染性がある.
- 人間は,CWDに感染した鹿類の肉を食べたり,扱ったりすると,プリオンに曝露されるリスクがあります.
- CWDの感染リスクを軽減するために,さらなる研究と公衆衛生対策が必要である.
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