腹腔内部の改造に関する論争
Lionel H Opie1, Patrick J Commerford, Bernard J Gersh
1Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Faculty of Health Sciences, Observatory 7925, Cape Town, South Africa. Opie@capeheart.uct.ac.za
Lancet (London, England)
|January 31, 2006
まとめ
静脈再建は,心臓の構造的な変化を伴う.
科学分野:
- 心血管生物学と病理学.
- 心臓の改造メカニズム.
- 心不全の病理生理学 心不全の病理生理学
背景:
- 心室改造は,負荷条件の慢性的な変化による左心室の構造的変化を網羅する.
- 主なパターンは,同心的改造 (圧力負荷),特異的高縮 (体積負荷),および心筋梗塞を含む.
- 左心室縮の適応性対不適応性の性質は,大動脈狭窄とシグナル伝達経路の影響を伴って,議論されているままです.
研究 の 目的:
- 静脈再建の病理生理学と心不全への移行をレビューする.
- これらの複雑なプロセスを標的とした新興および新しい治療戦略について議論する.
主な方法:
- 静脈再建,高縮,心不全に関する既存の文献のレビュー.
- メカニズムの洞察に基づく潜在的な治療的介入の議論.
主要な成果:
- 心不全への移行には,メタロプロテインゼ,活性酸素種,および神経相性因子の複雑な相互作用が含まれています.
- 薬理学的薬剤,外科的介入,細胞ベースの治療など,いくつかの新しい治療法が提案されています.
結論:
- 静脈再建は,心不全の発達に重大な影響を及ぼすダイナミックなプロセスです.
- 特定の分子経路と機械的介入を標的とした新しい治療戦略は,心不全の管理に潜在的可能性を秘めています.
関連する概念動画
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Layers of the Heart Wall
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...


