単一分子DNAシーケンシングに向けて:分子アダプタを装備した人工タンパク質ナノポールを用いてリボヌクレオシドおよびデオキシリボヌクレオシド5'-モノフォスファートの直接識別

Yann Astier1, Orit Braha, Hagan Bayley

  • 1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, OX1 3TA, Oxford, UK.

まとめ

この研究は,改変されたタンパク質ナノポールは,核酸の配列化に向けた重要なステップである個々の核酸5'-モノフォスファットを検出できることを示しています. この単一分子の検出方法は,将来のDNAおよびRNAシーケンシング技術に希望を示しています.

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