メタ解析における出版バイアスを検出する2つの方法の比較
Jaime L Peters1, Alex J Sutton, David R Jones
1Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England. jlp9@leicester.ac.uk
JAMA
|February 10, 2006
まとめ
サンプルサイズに基づく新しい回帰テストは,オッズ比率 (lnOR) の自然ログを使用する際に,公開バイアスを検出するための適切なタイプIエラー率を示しています. この代替テストは,エッガーの回帰テストに匹敵する性能で,メタ分析のための信頼できる方法を提供します.
科学分野:
- バイオ統計学 バイオ統計学
- 医学研究方法論 医学研究方法論
- メタアナリシス メタ分析
背景:
- エッガーの回帰テストは,メタ解析における出版バイアスを特定するための一般的なツールです.
- エッガーのテストとフンネルプロットの信頼性は,オッズ比 (lnOR) の自然ログが要約推定値である場合に疑問視される.
- 出版バイアスはメタ分析の結果を歪め,エビデンスベースの医学に影響を与える可能性があります.
研究 の 目的:
- Eggerの回帰テストのパフォーマンスを新しいサンプルサイズベースの回帰テストと比較するために.
- これらのテストを評価するには,特にオッズ比 (lnOR) の自然ログが要約推定値として使用される場合です.
- 出版バイアスを検出する各テストの精度と力を評価する.
主な方法:
- シミュレーションされたメタアナリシスは,出版バイアスの存在や欠如,研究間の異質性を含む様々なシナリオの下で実施されました.
- タイプIエラー率 (偽陽性) は,エッガーの回帰テストと代替のサンプルサイズベースの回帰テストの両方で計算されました.
- 既存の出版バイアスを検出するための各テストの力 (真の陽性率) を評価した.
主要な成果:
- エッガーの回帰テストは,代替回帰テストと比較して,より高いタイプIエラー率を示した.
- 代替回帰テストは,異なる確率比,研究数,異質性レベルにおいて適切なタイプIエラー率を維持した.
- 研究間の異質性が低い場合,代替テストは,出版バイアスを検出する際のエッガーのテストに匹敵する能力を示しました.
結論:
- 代替回帰テストは適切なタイプIエラー率を示し,lnORとその分散の相関を減少させます.
- このサンプルサイズベースの回帰テストは,lnORを要約推定値として使用する際のエッガーの回帰テストの代わりとして推奨されます.
- この結果は,InOR推定値を用いたメタ解析において,より信頼性の高い出版バイアス検出のための代替テストの使用を支持する.
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