成長と代謝におけるTORシグナル伝達
Stephan Wullschleger1, Robbie Loewith, Michael N Hall
1Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Cell
|February 14, 2006
まとめ
ラパミシン (TOR) の標的は,細胞の成長と代謝を調節する. 哺乳類のTORを阻害することで,がん,心血管,自己免疫,代謝疾患の治療が可能である.
科学分野:
- バイオケミストリー バイオケミストリー
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- ラパミシン (TOR) の標的は,種間で保存される重要なSer/Thrキナーゼです.
- TORシグナリングは,細胞の成長と代謝を制御するために環境のシグナルを統合します.
- 哺乳類のTORは,TORC1とTORC2という2つの異なるマルチタンパク質複合体の中で機能する.
研究 の 目的:
- ラパマイシン (mTOR) 複合体の哺乳類の標的をレビューする.
- mTORによって媒介されるシグナル伝達経路を解明する.
- mTOR阻害剤の治療の可能性を強調する.
主な方法:
- 既存の文献とモデル生物の研究のレビュー.
- mTORC1とmTORC2.2の構造と機能の分析
- mTORC1不調の生理学的結果の検討.
主要な成果:
- mTORは,ラパミシン感受性TORC1とラパミシン感受性TORC2.2という2つの異なる複合体で存在します.
- TORC1とTORC2は,異なる細胞プロセスを調節する.
- 哺乳類のTORC1の調節不良は,様々な疾患に起因しています.
結論:
- 哺乳類のTORC1とTORC2は,細胞の調節に重要な役割を果たしています.
- 哺乳類のTOR,特にTORC1を標的にすることは,治療的介入の有望性を示しています.
- mTOR阻害剤は,がん,心血管疾患,自己免疫,代謝障害に対する新しい治療戦略を提供することができる.
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