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Updated: Jul 4, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

ポリグルタミン系疾患のモデルにおける細胞タンパク質の折り畳みの漸進的な障害

Tali Gidalevitz1, Anat Ben-Zvi, Kim H Ho

  • 1Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.

Science (New York, N.Y.)
|February 14, 2006
PubMed
まとめ

病気に共通する誤った折りたたまれたタンパク質は,細胞のタンパク質の折りたたみを破壊する. 弱い変異は,これらのタンパク質集積疾患を悪化させ,神経変性に影響を与える可能性があります.

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Assays for the Degradation of Misfolded Proteins in Cells

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Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans06:49

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans

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