遺伝子規制ネットワークと動物の体プランの進化
Eric H Davidson1, Douglas H Erwin
1Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu
Science (New York, N.Y.)
|February 14, 2006
まとめ
動物のボディプランの進化は,遺伝子調節ネットワーク (GRNs) の変化に依存しています. GRN内の安定した"カーネル"コンポーネントは,プレカンブリア時代以来の主要なボディプランの保存を説明する可能性があります.
科学分野:
- 進化的発達生物学 進化的発達生物学
- 遺伝学とゲノミクス
背景:
- 動物のボディプランの発達は,複雑な遺伝子調節ネットワーク (GRNs) によって制御されます.
- ボディプランの進化は,これらの発達GRNsのアーキテクチャの変化と密接に関連しています.
- GRN内のコンポーネントは,変化する速度と進化の様子を表しています.
研究 の 目的:
- GRNアーキテクチャと動物のボディプランの進化の関係を調査する.
- 進化的変化に抵抗する可能性がある特定のGRN成分を特定する.
- 化石記録で観察された主要なボディプランの保存を説明するために.
主な方法:
- 発達中のGRNsの階層的な組織の分析.
- 異なる開発的役割と内部構造を持つGRNコンポーネントの識別.
- 異なる動物系におけるGRN進化の比較分析.
主要な成果:
- 発達型GRNは,変化が末尾の特徴や主要な形態学的側面に影響を与えるような階層的な構造を有しています.
- "カーネル"と呼ばれるGRNコンポーネントのクラスは,発達機能と内部構造のために変化に非常に抵抗性があるとして識別されました.
- 進化の歴史を通じてフィレティックな体プランの保存は,これらのGRNの核の保持に起因する可能性があります.
結論:
- 動物のボディプランの進化は,発達的なGRNsのアーキテクチャによって制約されています.
- GRNカーネルは,基本的なボディプランの特徴を維持する上で重要な役割を果たします.
- GRNの核の安定性は,カンブリア紀の初期の確立が示すように,主要なボディプランの長期保存のためのメカニズムを提供します.
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