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Updated: Jul 7, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

MEF2転写因子の活動依存的調節は,刺激シナプス数を抑制する

Steven W Flavell1, Christopher W Cowan, Tae-Kyung Kim

  • 1Neurobiology Program, Children's Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Science (New York, N.Y.)
|February 18, 2006
PubMed
まとめ

ミオサイト増強因子2 (MEF2) の転写因子は,ニューロンの活動に反応するシナプス数を制御する. 活性化されたMEF2は,神経系の発達中の遺伝子転写を促進することによって,刺激性シナプス形成を制限する.

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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome08:27

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