男性の乳がんは,
Ian S Fentiman1, Alain Fourquet, Gabriel N Hortobagyi
1Academic Oncology, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK. Ian.Fentiman@gstt.nhs.uk
Lancet (London, England)
|February 21, 2006
まとめ
男性の乳がんは,典型的には71歳で診断され,BRCA2変異と過剰エストロゲン化に関連しています. ほとんどの症例が進行段階にあるため,早期発見は極めて重要です.
科学分野:
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
- エピデミオロジー エピデミオロジー
背景:
- 男性の乳がんは珍しい疾患で,発症率は71歳くらいでピークに達する.
- 家族発症はBRCA1.1よりもBRCA2変異と関連していることが多い.
- 危険因子には,過剰エストロゲン化 (クラインフェルター症,肥満,アルコール) と放射線被曝が含まれます.
研究 の 目的:
- 男性の乳がんの流行病学,危険因子,発現,および管理についてまとめます.
- 早期発見と適切な治療戦略の重要性を強調する.
主な方法:
- 男性の乳がんに関する既存の文献のレビュー.
- 危険因子,臨床表現,病理,治療結果の分析.
主要な成果:
- 一般的な症状には,塊や乳首の逆転が挙げられるが,往々にして進行段階 (III/IV) にある.
- ほとんどの腫瘍は管道性であり,10%は管道性癌である.
- エストロゲン受容体陽性腫瘍 (90%) はタモキシフェンとホルモン療法に良好な反応を示します.
結論:
- 男性の乳がんの管理は,女性乳がんと並行して,手術,放射線治療,ホルモン療法を主軸にしています.
- 化学療法は,特に転移性疾患の場合,一部の患者に有益である可能性があります.
- 男性の乳がん患者に対して,よりよい国家支援と情報提供の取り組みが必要である.
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