高解像度の生命の樹の自動再構築に向けて

Francesca D Ciccarelli¹, Tobias Doerks, Christian von Mering

¹European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

Science (New York, N.Y.)

|March 4, 2006

まとめ

この研究は,生命の樹を191種の31のオーソログを使って再構築しています. 横断的な遺伝子転送製品を削除することで,系統遺伝子の解像度が向上し,関係を確認し,分類を解決しました.

科学分野:

進化生物学の進化生物学について
フィロジェネティクスフィルジェネティクス
ゲノミクスゲノミクスとは

背景:

生命の樹を再構成することは,進化の歴史を理解するために極めて重要です.
以前の系統遺伝分析は,水平遺伝子の移転と分類学的不一致のために課題に直面しています.

研究の目的:

生命の樹を高解像度で再構築するための自動化された手順を開発する.
系統的に,水平に転移した遺伝子を特定し,排除することによって,系統遺伝子の解像度を向上させる.
論争の的および予備的な分類分類を解決するために.

主な方法:

配列化されたゲノムを持つ191種の31のオートロゴス遺伝子の連鎖.
横に転移した遺伝子産物の体系的な検出と排除.
比較可能な枝の長さで生命の樹を再構築するための系統遺伝分析.

主要な成果:

再構築された樹は,分類分類の領域間不一致を明らかにした.
横断的な遺伝子転送製品を除外すると,系統遺伝学的な解像度が向上した.
認められた系統遺伝的関係を確認し,論争の的だった分類を解決した.
アシドバクテリアをデルタ・プロテオバクテリアの姉妹群として配置した.
細菌のグラム陽性起源を支持した.
熱愛的な最後の普遍的な共通の祖先が示唆された.

結論:

開発された方法は,生命の樹の再構築のための堅固な枠組みを提供します.
正確な系統遺伝的推論には,水平遺伝子の移転を考慮する必要があります.
この研究は,生命の初期の進化と細菌分類に関する新しい洞察を提供します.

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