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関連する概念動画

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Jul 14, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

表面改変タンパク質マイクロ球によって腫瘍を標的とする.

Farah Jean-Jacques Toublan1, Stephen Boppart, Kenneth S Suslick

  • 1Department of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|March 16, 2006
PubMed
まとめ

研究者らは,標的がん治療のためにRGDペプチド改変タンパク質マイクロスフィアを開発した. これらの新しい微球は,腫瘍細胞による選択的結合と吸収を実証し,生物医学アプリケーションにおける以前の表面改変の課題を克服しました.

科学分野:

  • バイオマテリアル科学 バイオマテリアル科学
  • ナノテクノロジー ナノテクノロジー
  • 腫瘍学 腫瘍学

背景:

  • タンパク質マイクロスフィアは,生物医学画像と薬物投与に使用されています.
  • 標的細胞の配送のための表面改変は,依然として重要な課題です.

研究 の 目的:

  • 腫瘍細胞にタンパク質の微球を標的とする新しい方法を開発する.
  • 表面機能化のための静電粘着の使用を調査する.

主な方法:

  • 静電粘着アプローチを用いて,アルギニン-グルタミン酸-アスパルティック酸 (RGD) ペプチドを血清アルブミンのコアシェルマイクロ球に結合した.
  • 表面改変のためのRGD配列を含むポリリシンペプチドが使用されています.
  • ヒト結腸がん細胞のHT29を用いた標的付けを in vitroで調査した.

主要な成果:

  • 血清アルブミン微球の表面をRGDを含むペプチドで成功裏に修正しました.
  • 改変した微球がHT29結腸がん細胞に選択的に結合することを実証した.
  • 光顕微鏡を用いた癌細胞によるRGD改変微球の細胞吸収が確認された.

結論:

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Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
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Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

関連する実験動画

Last Updated: Jul 14, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
08:24

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

Published on: June 12, 2016

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

  • 静電粘着は,RGDペプチドによるタンパク質微球の表面改変のための効果的な戦略です.
  • RGD改変型タンパク質マイクロスフィアは,腫瘍細胞に標的を絞り込むことを有望に示しています.
  • このアプローチは,標的がん治療における以前の限界を克服するための潜在的な解決策を提供します.